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  Indian J Med Microbiol
 

Figure 1: The neuroprotective effect of CO on ischemic stroke and hemorrhagic stroke. Note: ARE: Antioxidant response element; cGMP: cyclic guanosine phosphate; CO: carbon monoxide; CORM-3: carbon monoxide releasing molecule 3; eNOS: endothelial nitric oxide synthase; HO-1: heme oxygenase-1; Iba-1: ionized calcium-binding adaptor molecule-1; IL-1β: interleukin-1β; iNOS: inducible nitric oxide synthase; Keap-1: Kelch-like ECH-associated protein 1; LN: laminin; MMP-9: matrix metalloproteinase-9; NO: nitric oxide; NPAS-2:neuronal PAS domain protein 2; Nrf: nuclear factor erythroid 2-related factor; PDGFR-β: platelet-derived growth factor receptor-β; Per: period; PGC-1α: peroxisome proliferator-activated receptor-γ coactivator-1α; Prx I: peroxidase I; ROS: reactive oxygen species; TFAM: mitochondrial transcription factor A; TNF-α: tumor necrosis factor-α; ZO-1: zonula occluden-1.

<b>Figure 1: The neuroprotective effect of CO on ischemic stroke and hemorrhagic stroke.</b>
Note: ARE: Antioxidant response element; cGMP: cyclic guanosine phosphate; CO: carbon monoxide; CORM-3: carbon monoxide releasing molecule 3; eNOS: endothelial nitric oxide synthase; HO-1: heme oxygenase-1; Iba-1: ionized calcium-binding adaptor molecule-1; IL-1β: interleukin-1β; iNOS: inducible nitric oxide synthase; Keap-1: Kelch-like ECH-associated protein 1; LN: laminin; MMP-9: matrix metalloproteinase-9; NO: nitric oxide; NPAS-2:neuronal PAS domain protein 2; Nrf: nuclear factor erythroid 2-related factor; PDGFR-β: platelet-derived growth factor receptor-β; Per: period; PGC-1α: peroxisome proliferator-activated receptor-γ coactivator-1α; Prx I: peroxidase I; ROS: reactive oxygen species; TFAM: mitochondrial transcription factor A; TNF-α: tumor necrosis factor-α; ZO-1: zonula occluden-1.