Medical Gas Research

RESEARCH ARTICLE
Year
: 2023  |  Volume : 13  |  Issue : 2  |  Page : 59--66

Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study


Anna Vaycheslavovna Deryugina1, Darya Andreevna Danilova1, Yurii Dmitrievich Brichkin2, Evgenii Vladimirovich Taranov2, Evgenii Ivanovich Nazarov3, Vladimir Viktorovich Pichugin2, Aleksandr Pavlovich Medvedev4, Michail Valerevich Riazanov2, Sergey Andreevich Fedorov2, Yurevich Smorkalov Andrej2, Evgenii Vladimirovich Makarov2 
1 Department of Physiology and Anatomy, Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation
2 Specialized Clinical Cardiac Surgery Hospital, Nizhny Novgorod, Russian Federation
3 Limited Liability Company “Research and Production Enterprise” Ekonika, Odesa, Ukraine, Russian Federation
4 Specialized Clinical Cardiac Surgery Hospital; Department of Hospital Surgery named after B.A. Korolev, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russian Federation

Correspondence Address:
Darya Andreevna Danilova
Department of Physiology and Anatomy, Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation
Russian Federation

Molecular hydrogen (H2) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical trial was conducted with 20 patients referring to the Specialized Cardiosurgical Clinical Hospital, Nizhny Novgorod, Russian Federation, who underwent elective surgery with CPB. Twenty-four patients were randomly assigned to two groups. First group included 12 patients (research group) who received H2 at a concentration of 1.5–2.0% through a facemask using a breathing circuit of the ventilator together with anesthesia immediately after tracheal intubation and throughout the operation. Second group (control group) included 12 patients who were not given H2. Blood samples were withdrawn from peripheral veins and radial artery at four stages: immediately after the introduction of anesthesia (stage 1), before the start of CPB (stage 2), immediately after its termination (stage 3) and 24 hours after the operation (the early postoperative period) (stage 4). An increase in electrophoretic mobility, an increase in the metabolism of red blood cells, and a decrease in the aggregation of red blood cells relative to the corresponding indicators of the control group were observed in the research group. Patients in the research group had a decrease in oxidative stress manifestations most pronounced one day after the operation. There was a statistically significant difference between the indicators of myocardial contractile function in the research and control group on the 1st and 3rd days after surgery. H2 inhalation leads to improvement of functional state of red blood cells, which is accompanied by a more favorable course of the early postoperative period. These data show the presence of protective properties of molecular hydrogen.


How to cite this article:
Deryugina AV, Danilova DA, Brichkin YD, Taranov EV, Nazarov EI, Pichugin VV, Medvedev AP, Riazanov MV, Fedorov SA, Andrej YS, Makarov EV. Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study.Med Gas Res 2023;13:59-66


How to cite this URL:
Deryugina AV, Danilova DA, Brichkin YD, Taranov EV, Nazarov EI, Pichugin VV, Medvedev AP, Riazanov MV, Fedorov SA, Andrej YS, Makarov EV. Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study. Med Gas Res [serial online] 2023 [cited 2022 Nov 27 ];13:59-66
Available from: https://www.medgasres.com/article.asp?issn=2045-9912;year=2023;volume=13;issue=2;spage=59;epage=66;aulast=Deryugina;type=0