Medical Gas Research

REVIEW
Year
: 2023  |  Volume : 13  |  Issue : 1  |  Page : 7--9

Therapeutic applications of hydrogen sulfide and novel donors for cerebral ischemic stroke: a narrative review


Jia-Sheng Ding, Yan Zhang, Tian-Yi Wang, Xiang Li, Cheng Ma, Zhong-Mou Xu, Qing Sun, Xiang Xu, Gang Chen 
 Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China

Correspondence Address:
MD Qing Sun
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province
China
MD Xiang Xu
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province
China

Ischemic stroke happens when the blood supply to the brain is obstructed and it is associated with numerous complex mechanisms, such as activated apoptosis genes, oxidative stress and reaction of inflammation, which finally result in neurological deficits. Several gases have been proved to have neuroprotective roles, even the classic gases that are thought to be toxic such as hydrogen sulfide (H2S). H2S is the third identified endogenous gas signaling molecule following carbon monoxide and nitric oxide. H2S plays a significant role in stroke. Inhalation of H2S can attenuate cerebral infarct volume and promote neurological function in a rat model of middle cerebral artery occlusion to reduce ischemic stroke-induced injury in vivo and in vitro as a result. Therefore, H2S can be clinically used to reduce ischemic stroke-induced injury. This review introduces the toxic mechanisms and effects of H2S on cerebral ischemic stroke


How to cite this article:
Ding JS, Zhang Y, Wang TY, Li X, Ma C, Xu ZM, Sun Q, Xu X, Chen G. Therapeutic applications of hydrogen sulfide and novel donors for cerebral ischemic stroke: a narrative review.Med Gas Res 2023;13:7-9


How to cite this URL:
Ding JS, Zhang Y, Wang TY, Li X, Ma C, Xu ZM, Sun Q, Xu X, Chen G. Therapeutic applications of hydrogen sulfide and novel donors for cerebral ischemic stroke: a narrative review. Med Gas Res [serial online] 2023 [cited 2022 Aug 9 ];13:7-9
Available from: https://www.medgasres.com/article.asp?issn=2045-9912;year=2023;volume=13;issue=1;spage=7;epage=9;aulast=Ding;type=0