Medical Gas Research

RESEARCH ARTICLE
Year
: 2022  |  Volume : 12  |  Issue : 3  |  Page : 91--99

Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum


Yoshiharu Tanaka1, Li Xiao2, Nobuhiko Miwa3 
1 Division of Biology, Faculty of Liberal Arts and Sciences, and Division of Quantum Radiation, Faculty of Technology, Osaka Prefecture University, Osaka, Japan
2 Department of Pharmacology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan
3 Incorporated Association Institute for Hydrogen Medicine, Hyogo; Faculty of Life Sciences, Prefectural University of Hiroshima, Hiroshima, Japan

Correspondence Address:
Yoshiharu Tanaka
Division of Biology, Faculty of Liberal Arts and Sciences, and Division of Quantum Radiation, Faculty of Technology, Osaka Prefecture University, Osaka
Japan

This study compared the effects of hydrogen-water (HW) bath on the oxygen radical absorption-based antioxidant capacity and the inflammatory indicator, C-reactive protein (CRP), in serum between healthy volunteers and inflammatory/collagen disease-patients. The HW bath apparatus supplied nano-bubbles with a diameter of 110 ± 10 nm and 338–682 μg/L of dissolved hydrogen after 120 minutes electrolysis, and nano-bubbles increased to 9.91 × 107/mL along with the increase of correlative dissolved hydrogen. Ten-minute HW bath increased the oxygen radical absorption-based antioxidant capacity to 110.9 ± 9.2% at post-bathing 120 minutes, although unaltered with 10-minute normal water bath at 40°C in healthy subjects. The CRP level was repressed to 70.2 ± 12.1% at 120 minutes after HW bath, although rather increased for normal water bath. In the patients with connective tissue diseases, the CRP level was repressed to 3–24% upon 9 days to 4 months of HW bathing. In another six patients with diverse autoimmune-related diseases, upon daily HW bathing as long as 2–25 months, the pre-bathing CRP level of 5.31 mg/dL decreased to 0.24 mg/dL being within the standard-range, with relief of visible inflammatory symptoms for some cases. Thus, the HW bath with high-density nano-bubbles has beneficial effects on serum antioxidant capacity, inflammation, and the skin appearance. The study was approved by the Committee of Ethics, Japanese Center of Anti-Aging Medical Sciences (Authorization No. H-15-03-2, on January 15, 2019), which was a non-profitable organization officially authenticated by the Hiroshima Prefecture Government of Japan.


How to cite this article:
Tanaka Y, Xiao L, Miwa N. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.Med Gas Res 2022;12:91-99


How to cite this URL:
Tanaka Y, Xiao L, Miwa N. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum. Med Gas Res [serial online] 2022 [cited 2022 Jan 22 ];12:91-99
Available from: https://www.medgasres.com/article.asp?issn=2045-9912;year=2022;volume=12;issue=3;spage=91;epage=99;aulast=Tanaka;type=0