Medical Gas Research

REVIEW
Year
: 2022  |  Volume : 12  |  Issue : 3  |  Page : 73--76

Current research progress of isoflurane in cerebral ischemia/reperfusion injury: a narrative review


Shu-Jun Chen1, Xia-Qing Yuan1, Qun Xue1, Hai-Feng Lu1, Gang Chen2 
1 Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
2 Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China

Correspondence Address:
Hai-Feng Lu
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province
China
Qun Xue
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province
China

Cerebral ischemia/reperfusion injury is an important factor leading to poor prognosis in ischemic stroke patients. Therefore, it is particularly important to find effective remedial measures to promote the health of patients to return to society. Isoflurane is a safe and reliable anesthetic gas with a long history of clinical application. In recent years, its protection function to human body has been widely recognized, and nowadays isoflurane for cerebral protection has been widely studied, and the stable effect of isoflurane has satisfied many researchers. Basic studies have shown that isoflurane’s protection of brain tissue after ischemia/reperfusion involves a variety of signaling pathways and effector molecules. Even though many signaling pathways have been described, more and more studies focus on exploring their mechanisms of action, in order to provide strong evidence for clinical application. This could prompt the introduction of isoflurane therapy to clinical patients as soon as possible. In this paper, several confirmed signaling pathways will be reviewed to find possible strategies for clinical treatment.


How to cite this article:
Chen SJ, Yuan XQ, Xue Q, Lu HF, Chen G. Current research progress of isoflurane in cerebral ischemia/reperfusion injury: a narrative review.Med Gas Res 2022;12:73-76


How to cite this URL:
Chen SJ, Yuan XQ, Xue Q, Lu HF, Chen G. Current research progress of isoflurane in cerebral ischemia/reperfusion injury: a narrative review. Med Gas Res [serial online] 2022 [cited 2022 Jan 22 ];12:73-76
Available from: https://www.medgasres.com/article.asp?issn=2045-9912;year=2022;volume=12;issue=3;spage=73;epage=76;aulast=Chen;type=0