Medical Gas Research

REVIEW
Year
: 2022  |  Volume : 12  |  Issue : 2  |  Page : 41--43

Perioperative melatonin in COVID-19 patients: benefits beyond sedation and analgesia


Abhijit S Nair 
 Department of Anaesthesiology, Ibra Hospital, Ministry of Health-Oman, Ibra, Sultanate of Oman

Correspondence Address:
Abhijit S Nair
Department of Anaesthesiology, Ibra Hospital, Ministry of Health-Oman, Ibra
Sultanate of Oman

Cytokine storm in coronavirus disease 2019 (COVID-19) patients leads to acute lung injury, acute respiratory distress syndrome, multiorgan dysfunction, shock, and thrombosis thus contributing to significant morbidity and mortality. Several agents like steroids, ascorbic acid, vitamins (C, D, E), glutathione, N-acetylcysteine have been used and several studies are underway to identify its efficacy in addressing undesirable effects due to COVID-19 illness. Among several experimental modalities based on expert opinion and anecdotal data, melatonin is one molecule that appears promising. Owing to its anti-inflammatory, anti-oxidant, and immunomodulatory properties, melatonin can be an important agent used as a component of multimodal analgesia in COVID-19 patients, suspected patients, and patients with exposure to positive patients undergoing emergency or urgent surgeries. Further research is required to know the optimal time of initiation, dose, and duration of melatonin as an adjunct.


How to cite this article:
Nair AS. Perioperative melatonin in COVID-19 patients: benefits beyond sedation and analgesia.Med Gas Res 2022;12:41-43


How to cite this URL:
Nair AS. Perioperative melatonin in COVID-19 patients: benefits beyond sedation and analgesia. Med Gas Res [serial online] 2022 [cited 2021 Dec 8 ];12:41-43
Available from: https://www.medgasres.com/article.asp?issn=2045-9912;year=2022;volume=12;issue=2;spage=41;epage=43;aulast=Nair;type=0