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Argon pharmacokinetics: a solubility measurement technique
Joël Lemaire1, Michel Heninger1, Essyllt Louarn1, Ira Katz2, Renaud Tissier3, Matthieu Chalopin2, Géraldine Farjot2, Aude Milet2
1 Institut de Chimie Physique, Centre National de la Recherche Scientifique, Université Paris-Saclay, Orsay, France
2 Medical Research and Development, Air Liquide Santé International, Les loges-en-Josas, France
3 Univ Paris Est Créteil, Institut National de la Santé et de la Recherche Médicale, Mondor Institute for Biomedical Research, Créteil; Ecole Nationale Vétérinaire d’Alfort, Mondor Institute for Biomedical Research, Maisons-Alfort, France
Correspondence Address:
Ira Katz,
Correspondence to: Ira Katz, PhD
France
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/2045-9912.351106
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The noble gas argon has demonstrated biological activity that may prove useful as a medical intervention. Pharmacokinetics, the disposition of the drug molecule in the body through time, is fundamental necessary knowledge to drug discovery, development and even post-marketing. The fundamental measurement in pharmacokinetic studies is blood concentration of the molecule (and its metabolites) of interest. While a physiologically based model of argon pharmacokinetics has appeared in the literature, no experimental data have been published. Thus, argon pharmaceutical development requires measurement of argon solubility in blood. This paper reports on the development of a technique based on mass spectrometry for measuring argon solubility in liquids, including blood, to be further employed in pharmacokinetics testing of argon. Based on a prototype, results are reported from sensitivity experiments using ambient air, water and rabbit blood. The key takeaway is that the system was sensitive to argon during all of the testing. We believe the technique and prototype of the quadrupole mass spectrometer gas analyzer will be capable of inferring argon pharmacokinetics through the analysis of blood samples.
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