Nitric oxide therapy is beneficial to rehabilitation in professional soccer players: clinical and experimental studies Zaborova VA, Butenko AV, Shekhter AB, Fayzullin AL, Pekshev AV, Serejnikova NB, Chigirintseva OV, Kryuchkova KY, Gurevich KG,

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RESEARCH ARTICLE

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Nitric oxide therapy is beneficial to rehabilitation in professional soccer players: clinical and experimental studies Victoria A Zaborova¹, Alexandra V Butenko², Anatoly B Shekhter³, Alexey L Fayzullin², Alexander V Pekshev⁴, Natalia B Serejnikova³, Ol'ga V Chigirintseva⁵, Kira Yu Kryuchkova⁶, Konstantin G Gurevich⁷ ¹ Department of Sports Medicine and Medical Rehabilitation, Institute of Clinical Medicine, Sechenov University; Sports Adaptology Lab, Moscow Institute of Physics and Technology (National Research University), Moscow, Russian Federation ² Institute for Regenerative Medicine; World-Class Research Center “Digital Biodesign and Personalized Healthcare,” Sechenov University, Moscow, Russian Federation ³ Institute for Regenerative Medicine, Sechenov University, Moscow, Russian Federation ⁴ Research Institute of Power Engineering, Bauman Moscow State Technical University, Moscow, Russian Federation ⁵ Sports Adaptology Lab, Moscow Institute of Physics and Technology (National Research University), Moscow, Russian Federation ⁶ Department of Sports Medicine and Medical Rehabilitation, Institute of Clinical Medicine, Sechenov University, Moscow, Russian Federation ⁷ UNESCO Chair «Healthy Lifestyle for Successful Development», Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russian Federation Correspondence Address: Victoria A Zaborova, Department of Sports Medicine and Medical Rehabilitation, Institute of Clinical Medicine, Sechenov University; Sports Adaptology Lab, Moscow Institute of Physics and Technology (National Research University), Moscow Russian Federation Source of Support: None, Conflict of Interest: None DOI: 10.4103/2045-9912.344983

Nitric oxide can activate neutrophils and macrophages, facilitate the synthesis of collagen, which allows significantly accelerating the regeneration of traumatized tissues. We studied the effects of nitric oxide-containing gas flow generated by plasma-chemical device “Plason” in a rat model of full-thickness wounds. Histological and morphometric analyses revealed that Plason treated wounds expressed significantly fewer signs of inflammation and contained a more mature granulation tissue on day 4 after the operation. Considering the results of the experimental study, we applied the Plason device in sports medicine for the treatment of lower limb bruises of 34 professional soccer players. Athletes were asked to assess the intensity of pain with the Visual Analogue Scale. Girths of their lower limbs were measured over the course of rehabilitation. Nitric oxide therapy of full-thickness wounds inhibited inflammation and accelerated the regeneration of skin and muscle tissues. Compared with the control, we observed a significant reduction in pain syndrome on days 2–7 after injuries, edema, and hematoma, and shortened treatment duration. This pilot study indicates that the use of nitric oxide is a promising treatment method for sports injuries.

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