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Trend of research on the medical use of molecular hydrogen: a bibliometric analysis
He Li1, Hong-Yu Ma2, Wei-Long Hua2, Yong-Xin Zhang2, Lei Zhang2, Peng-Fei Xing2, Peng-Fei Yang2, Jian-Min Liu2
1 Emergency Department, Naval Hospital of Eastern Theater, Zhoushan, Zhejiang Province; Neurovascular Center, Changhai Hospital, Shanghai, China
2 Neurovascular Center, Changhai Hospital, Shanghai, China
Correspondence Address:
Jian-Min Liu,
Neurovascular Center, Changhai Hospital, Shanghai
China
Peng-Fei Yang,
Neurovascular Center, Changhai Hospital, Shanghai
China
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/2045-9912.344980
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The medical use of molecular hydrogen, including hydrogen-rich water and hydrogen gas, has been extensively explored since 2007. This article aimed to demonstrate the trend in medical research on molecular hydrogen. A total of 1126 publications on hydrogen therapy were retrieved from the PubMed database until July 30, 2021. From 2007 to 2020, the number of publications in this field had been on an upward trend. Medical Gas Research, Scientific Report and Shock have contributed the largest number of publications on this topic. Researchers by the name of Xue-Jun Sun, Ke-Liang Xie and Yong-Hao Yu published the most studies in the field. Analysis of the co-occurrence of key words indicated that the key words “molecular hydrogen,” “hydrogen-rich water,” “oxidative stress,” “hydrogen gas,” and “inflammation” occurred most frequently in these articles. “Gut microbiota,” “pyroptosis,” and “COVID-19” occurred the most recently among the keywords. In summary, the therapeutic application of molecular hydrogen had attracted much attention in these years. The advance in this field could be caught up by subscribing to relevant journals or following experienced scholars. Oxidative stress and inflammation were the most important research directions currently, and gut microbiota, pyroptosis, and coronavirus disease 2019 might become hotspots in the future.
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