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Year : 2023  |  Volume : 13  |  Issue : 3  |  Page : 94-98

Molecular hydrogen therapy for neurological diseases: a review of current evidence

1 Department of Neurosurgery, Loma Linda University, Loma Linda, CA, USA
2 Department of Neurosurgery, Loma Linda University; Department of Basic Sciences, Loma Linda University, Loma Linda, CA, USA

Correspondence Address:
Warren Boling
Department of Neurosurgery, Loma Linda University, Loma Linda, CA
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2045-9912.359677

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Reactive oxygen species and other free radicals cause oxidative stress which is the underlying pathogenesis of cellular injury in various neurological diseases. Molecular hydrogen therapy with its unique biological property of selectively scavenging pathological free radicals has demonstrated therapeutic potential in innumerable animal studies and some clinical trials. These studies have implicated several cellular pathways affected by hydrogen therapy in explaining its anti-inflammatory and antioxidative effects. This article reviews relevant animal and clinical studies that demonstrate neuroprotective effects of hydrogen therapy in stroke, neurodegenerative diseases, neurotrauma, and global brain injury.

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