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REVIEW
Year : 2022  |  Volume : 12  |  Issue : 4  |  Page : 125-130

Devil or angel: two roles of carbon monoxide in stroke


1 Department of Neurosurgery, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, Jiangsu Province, China
2 Department of Rehabilitation, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, Jiangsu Province, China
3 Department of Neurosurgery and Translational Medicine Center, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, Jiangsu Province, China
4 Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China

Correspondence Address:
Di Li
Department of Neurosurgery and Translational Medicine Center, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, Jiangsu Province
China
Hui-Xiang Liu
Department of Neurosurgery, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, Jiangsu Province
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2045-9912.337993

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Stroke is one of the most important acute diseases that endanger human health and result in death, including acute cerebral hemorrhage and acute cerebral ischemia. Acute onset is its most prominent feature. Carbon monoxide (CO) is a colorless and odorless gas existing at room temperature. It is not only a common air pollutant, but also has been found to be closely related to stroke. A large amount of exogenous CO has an important impact on the incidence and prognosis of stroke, while endogenous CO as a gas signal also has an important impact on neuroprotection after stroke. Both low-dose CO inhalation and CO-releasing molecule-3 (a molecule that emits CO) treatment have shown the benefits of stroke, and perhaps the role of CO in stroke is one of the key areas for future research.


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